Haematological, physiological and survival data in a porcine model of adult respiratory distress syndrome induced by endotoxaemia: effects of treatment with N-acetylcysteine

摘要: The effects of N-acetylcysteine (NAC)--which is supposed to act as a free radical scavenger--were evaluated on lung function, haemodynamics and oxygen transport in porcine model pulmonary cardiovascular failure induced by endotoxaemia. Three pigs, serving controls, received NAC without endotoxin (E) for 6 h, no notable physiological changes were found. Five pigs continuous infusion E alone h displayed 90% decrease leukocyte count 66% platelet count. Physiologically four-fold increase venous admixture (Qva/Qt), nearly 2-3 fold mean arterial pressure (MPAP) progressive decline cardiac output (Qt) 60% documented. Extravascular water (EVLW) increased 66%, (MAP) decreased 46% delivery 52%, leading metabolic acidosis. animals died during the observation period. Contrastingly, eight pretreated with 150 mg.kg-1 which was continued at 20 mg.kg-1.h-1, showed significantly attenuated response E. Thus, counts 70% 48%, respectively. Qva/Qt 2.5-3 fold, MPAP 1.3-2 Qt 32%. EVLW 27%, MAP 27% only 33% kept pH normal range. All survived period, significant difference from group. all monitored haematological pathophysiological ARDS pigs. In addition reported scavenger effect NAC, our results support assumption that may counteract aggregation thereby contributing beneficial outcome.