Microencapsulation and Nanoencapsulation Using Supercritical Fluid (SCF) Techniques.
作者： Soon Hong Soh , Lai Yeng Lee
DOI: 10.3390/PHARMACEUTICS11010021
关键词: Supercritical carbon dioxide 、 Spray drying 、 Particle 、 Fluidized bed 、 Process engineering 、 Supercritical drying 、 Supercritical fluid extraction 、 Particle size 、 Supercritical fluid 、 Materials science
摘要: The unique properties of supercritical fluids, in particular carbon dioxide (CO2), provide numerous opportunities for the development processes pharmaceutical applications. One potential applications pharmaceuticals includes microencapsulation and nanoencapsulation drug delivery purposes. Supercritical CO2 allow design control particle size, as well loading by utilizing tunable at different operating conditions (flow ratio, temperature, pressures, etc.). This review aims to a comprehensive overview techniques using fluid processing based on properties, role during process, mechanism formulation production each process discussed. considerations equipment configurations achieve various described mechanisms behind representative such RESS (rapid expansion solutions), SAS (supercritical antisolvent), SFEE extraction emulsions), PGSS (particles from gas-saturated drying, polymer foaming will be explained via schematic representation. More recent developments fluidized bed coating fluidizing drying medium, spray aqueous solutions, microporous releasing devices foaming, highlighted this review. Development strategies optimize morphology, loading, yield major also
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