Brain Cancer Stem Cells in Adults and Children: Cell Biology and Therapeutic Implications.

摘要: Brain tumors represent some of the most malignant cancers in both children and adults. Current treatment options target majority tumor cells but do not adequately self-renewing cancer stem (CSCs). CSCs have been reported to resist aggressive radiation chemotherapies, give rise recurrent, treatment-resistant secondary malignancies. With advancing technologies, we now a better understanding genetic, epigenetic molecular signatures microenvironmental influences which are useful distinguishing between distinctly different subtypes. As result, efforts underway identify within various subtypes based on this foundation. This review discusses progress CSC biology as it relates targeted therapies may be uniquely pediatric adult brain tumors. Studies date suggest that benefit more from genetic therapies, while combination treatments aimed specifically at multiple pathways effective treating seem greater propensity towards interactions. Ultimately, targeting approaches with current clinical potential owing their ability compromise maintenance mechanisms underlie highly deadly nature.