A bold view of the lactating brain: functional magnetic resonance imaging studies of suckling in awake dams.
作者： M. Febo
DOI: 10.1111/J.1365-2826.2011.02184.X
关键词: Sensory system 、 Psychology 、 Striatum 、 Olfactory system 、 Auditory cortex 、 Gustatory cortex 、 Sensory processing 、 Prefrontal cortex 、 Neuroscience 、 Functional magnetic resonance imaging
摘要: Functional magnetic resonance imaging (fMRI) has been used to investigate the responsiveness of maternal rat brain pup-suckling under various experimental paradigms. Our research employing lactating model explored cortical sensory processing pup stimuli and effect suckling on brain's reward system. Suckling was observed increase blood-oxygen-level-dependent (BOLD) signal intensity in midbrain, striatum prefrontal cortex, which are areas that receive prominent dopaminergic inputs. The BOLD activation system occurs parallel with extensive areas. regions include olfactory auditory cortex gustatory could correspond representations odours, vocalisations taste active during lactation. Activation patterns within consistent past motivation we explore possibility exposure drugs abuse might be disruptive neural responses pups, particularly cortex. ongoing fMRI studies support extend its functional neurocircuitry.
sci-hub.se 参考文章(100)
Jing-Yu Chang, Patricia H. Janak, Donald J. Woodward, Comparison of Mesocorticolimbic Neuronal Responses During Cocaine and Heroin Self-Administration in Freely Moving Rats The Journal of Neuroscience. ,vol. 18, pp. 3098- 3115 ,(1998) , 10.1523/JNEUROSCI.18-08-03098.1998
Brandi J. Mattson, Sharon E. Williams, Jay S. Rosenblatt, Joan I. Morrell, Preferences for cocaine- or pup-associated chambers differentiates otherwise behaviorally identical postpartum maternal rats. Psychopharmacology. ,vol. 167, pp. 1- 8 ,(2003) , 10.1007/S00213-002-1351-4
Joseph S. Lonstein, Judith M. Stern, Role of the Midbrain Periaqueductal Gray in Maternal Nurturance and Aggression: c-fos and Electrolytic Lesion Studies in Lactating Rats The Journal of Neuroscience. ,vol. 17, pp. 3364- 3378 ,(1997) , 10.1523/JNEUROSCI.17-09-03364.1997
C. A. Pedersen, J. M. Johns, I. Musiol, M. Perez-Delgado, G. Ayers, B. Faggin, J. D. Caldwell, Interfering with somatosensory stimulation from pups sensitizes experienced, postpartum rat mothers to oxytocin antagonist inhibition of maternal behavior. Behavioral Neuroscience. ,vol. 109, pp. 980- 990 ,(1995) , 10.1037/0735-7044.109.5.980
Judith M Stern, Y.-L Yu, David P Crockett, Dorsolateral columns of the spinal cord are necessary for both suckling-induced neuroendocrine reflexes and the kyphotic nursing posture in lactating rats. Brain Research. ,vol. 947, pp. 110- 121 ,(2002) , 10.1016/S0006-8993(02)02916-5
Hanbing Lu, Zheng-Xiong Xi, Leah Gitajn, William Rea, Yihong Yang, Elliot A Stein, Cocaine-induced brain activation detected by dynamic manganese-enhanced magnetic resonance imaging (MEMRI) Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 2489- 2494 ,(2007) , 10.1073/PNAS.0606983104
Marcelo Febo, Ada C. Felix-Ortiz, Tehya R. Johnson, Inactivation Or Inhibition Of Neuronal Activity In The Medial Prefrontal Cortex Largely Reduces Pup Retrieval And Grouping in Maternal Rats Brain Research. ,vol. 1325, pp. 77- 88 ,(2010) , 10.1016/J.BRAINRES.2010.02.027
Marcelo Febo, Ashley S. Pira, Increased BOLD activation to predator stressor in subiculum and midbrain of amphetamine-sensitized maternal rats. Brain Research. ,vol. 1382, pp. 118- 127 ,(2011) , 10.1016/J.BRAINRES.2010.11.092
Anna Lee, Sharon Clancy, Alison S Fleming, Mother rats bar-press for pups: effects of lesions of the mpoa and limbic sites on maternal behavior and operant responding for pup-reinforcement. Behavioural Brain Research. ,vol. 100, pp. 15- 31 ,(1999) , 10.1016/S0166-4328(98)00109-0
Ming Li, Alison S. Fleming, Differential involvement of nucleus accumbens shell and core subregions in maternal memory in postpartum female rats. Behavioral Neuroscience. ,vol. 117, pp. 426- 445 ,(2003) , 10.1037/0735-7044.117.3.426