Harnessing the self-assembly of peptides for the targeted delivery of anti-cancer agents

摘要: A significant challenge to current cancer drug treatment is mode of delivery, both in terms efficacy and off-target toxicity healthy tissues. To overcome this, localisation using a range biocompatible carriers currently use or under investigation. One class these biomaterial that offers unique prospect for as delivery vectors tumour sites hydrogels formed by small molecules. In particular, tissue mimetic self-assembling molecular can function either injectable precursors gelate response tumour-specific markers, implants conjunction with surgical resection debulking. Their inherent biocompatibility, tuneable properties, capacity flow situ allow them effectively transport, hold release therapeutic molecules spatially temporally controlled manner. This has been shown number vitro vivo studies, where they improve anti-cancer while reducing non-specific toxicity. However, further investigation required optimise systems toward the target tissue, provide sophisticated temporal control over presentation, determine most effective drug–material combinations specific types locations.