Regulation of Gene Expression in the Prostate
作者： R. J. Matusik , P. A. Cattini , K. J. Leco , P. C. Sheppard , B. E. Nickel
DOI: 10.1007/978-1-4615-3704-5_34
关键词: Regulation of gene expression 、 Androgen receptor 、 Transcription factor 、 Zinc finger 、 Hormone response element 、 DNA-binding domain 、 Cell biology 、 Biology 、 Receptor 、 Androgen
摘要: Cloning of the steroid receptors has demonstrated that they belong to a family transcription factors contain highly conserved “zinc finger” motif responsible for DNA binding (1). Using probes this domain, large number have been cloned, creating superfamily factors. Among cloned are those classic hormones (glucocorticoid, progesterone, estrogen, aldosterone, and androgen) related (thyroid, vitamin D3, retinoic acid). Additionally, approximately 10 (published) 15 (unpublished) identified whose functions remain unknown (2). These strong homology receptors, thus specific ligands predicted. new termed “orphan receptors” (2) in search ligand with function.
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