Brain involvement in organophosphate poisoning.

摘要: Abstract Organophosphate poisonings cause substantial morbidity and mortality worldwide; however, the neurological effects have not been clearly established. We studied cerebral perfusion to investigate neurotoxic effects. Clinical effects, plasma cholinesterase activity, brain single photon emission computerization tomography (SPECT) data were investigated in 16 patients with organophosphate poisonings. The subjects from an adult intensive care unit a university hospital. Cholinesterase activity was determined upon admission then every day morning. Brain SPECT studies performed during first week, at end of therapy, 3 months after discharge. Patients classified into groups using modified Namba classification: latent poisoning (Group A); mild moderate B); or severe C). None 6 Group A showed any symptoms; B had muscarinic nicotinic effects; 5 C muscarinic, nicotinic, central nervous system symptoms. average for Groups A, B, 54.16 ± 9.10, 42.2 12.02, 13 4.84 U/ml, respectively (normal range is 40–80 U/ml). Only 1 patient required treatment oxime; 2 all given oxime, atropine sulfate, mechanical ventilation. In studies, fewer defect areas than did patients. All cases defects especially parietal lobe. addition, improvement took more time other groups. stays statistically longer B. concluded that highly sensitive diagnostic method, together clinical symptoms monitoring prognosis