Repeated Cocaine Administration Attenuates Group I Metabotropic Glutamate Receptor-Mediated Glutamate Release and Behavioral Activation: A Potential Role for Homer

摘要: The present study aimed to characterize a functional role for group I metabotropic glutamate receptors (mGluRs) in the nucleus accumbens and capacity of repeated cocaine elicit long-term changes mGluR function. Reverse dialysis agonist ( RS )-3,5-dihydroxyphenylglycine (DHPG) into resulted an increase extracellular levels that was mediated by mGluR1 subtype depended on voltage-dependent Na+ Ca2+conductance. At 3 weeks after discontinuing 1 week daily injections, DHPG induce release markedly reduced. Similarly, induced mGluR1-dependent locomotor activity microinjection significantly blunted administration. Signaling through mGluRs is regulated, part, Homer proteins, it found blunting mGluR-induced motor associated with reduction Homer1b/c protein selective medial accumbens. These data show produces enduring inhibition neurochemical behavioral consequences stimulating accompanied scaffolding apparatus.