Immunological aspects of nanocellulose.

摘要: Abstract Cellulose is the most abundant natural polymer in world. Nanoscale forms of cellulose, including cellulose nanofibers (CNF), nanocrystals (CNC) and bacterial nanocellulose (BC), are very attractive industry, medicine pharmacy. Biomedical applications tissue engineering, regenerative medicine, controlled drug delivery promising. Nanocellulose considered a biocompatible nanomaterial relatively safe for biomedical applications. However, more studies needed to prove this hypothesis, especially those related chronic exposure nanocellulose. Besides toxicity, response immune system particular importance sense. This paper provides comprehensive critical review current-state knowledge impact on system, macrophages dendritic cells (DC), as central immunoregulatory cells, which has not been addressed literature sufficiently. Nanocellulose, CNC, can induce inflammatory upon internalization by macrophages, but reaction may be significantly modulated introducing different functional groups their surface. Our original results showed that potent immunotolerogenic potential. Native CNF potentiated capacity DC conventional Tregs. When carboxyl were introduced surface, tolerogenic potential was shifted towards induction regulatory CD8+ T whereas introduction phosphonates surface DCs’ both Type 1 (Tr-1) cells. These extremely important when considering application vivo, regeneration wound healing.