Regulation of Expression of Glutathione Peroxidase by Selenium
作者： R. A. Sunde , M. S. Saedi , S. A. B. Knight , C. G. Smith , J. K. Evenson
DOI: 10.1007/978-3-642-74421-1_2
关键词: Selenium in biology 、 Glutathione reductase 、 GPX5 、 Biochemistry 、 GPX4 、 GPX1 、 Chemistry 、 GPX3 、 GPX6 、 Glutathione peroxidase
摘要: Selenium was shown in 1957 to be an essential dietary nutrient for the rat (Schwarz and Foltz 1957). In same year, Mills (1957) reported discovery of enzyme, glutathione peroxidase (GSH-Px, GSH: H2O2 oxidoreductase, EC 1.11.1.9), that important protection erythrocytes against hemolysis. These two discoveries, plus apparent interaction sulfur compounds with Se GSH-Px, led J. T. Rotruck W. G. Hoekstra at Wisconsin 1971 identify GSH-Px as a Se-dependent enzyme (Rotruck et al. 1972, 1973). The background this described succinctly Second Biology Medicine Symposium 1981).
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