Clinically "small" effects of air pollution on FVC have a large public health impact. Swiss Study on Air Pollution and Lung Disease in Adults (SAPALDIA) - team.

摘要: Epidemiological studies have repeatedly established adverse health effects due to long-term exposure ambient air pollution. The Swiss Study on Air Pollution and Lung Disease in Adults (SAPALDIA) published a -3.14% decrease forced vital capacity (FVC) per 10 microg x m(-3) increment particulate matter (particles with 50% cut-off aerodynamic diameter of microm (PM(10)). Compared the within-subject variability FVC, effect may be considered small. This individual (or clinical) perspective is, however, misleading. purpose this study was demonstrate public relevance apparently "small" effects, using impact PM10 FVC as an example. scenario compares population A, exposed annual mean 20 m(-3), B 30 PM10. A shift distribution increases number subjects lower tail distribution. In relative increase expected 47% (16-91%) prevalence "FVC <80% predicted", (i.e., from 5.17 7.59% 5.88 8.65% among males females, respectively). <70% predicted" (approximately 1% population) 63% (30-98%, males) 57% (21-86%, females). An epidemiological estimate change value should not misinterpreted level. However, particles (PM10) clinically relevant reduction lung function is quantitatively important.