New Approaches to Identify Sepsis Biomarkers: The Importance of Model and Sample Source for Mass Spectrometry

摘要: Septic shock is a systemic inflammatory response syndrome associated with circulatory failure leading to organ 40% mortality rate. Early diagnosis and prognosis of septic are necessary for specific timely treatment. However, no predictive biomarker available. In recent years, improvements in proteomics-based mass spectrometry have improved the detection such biomarkers. This approach can be performed on different samples as tissue or biological fluids. Working directly from human complicated owing interindividual variability. Indeed, patients admitted at stages disease development signs varying severity one patient another. All these elements interfere identification early, sensitive, For reasons, animal models sepsis, although imperfect, used control kinetics pathology standardise experimentation, facilitating potential These underline importance choice model sample studied during preclinical studies. The aim this review discuss relevance approaches enable biomarkers that could indirectly relevant clinical setting.