Screening for breast cancer with mammography.

作者: Peter C Gøtzsche , Karsten Juhl Jørgensen

DOI: 10.1002/14651858.CD001877.PUB5

关键词: OverdiagnosisMedicineBreast cancer awarenessGynecologyMammographyMastectomyBreast cancerFamily medicineCancerObservational studyMass screening

摘要: Screening with mammography uses X-ray imaging to find breast cancer before a lump can be felt. The goal is treat earlier, when cure more likely. review includes seven trials that involved 600,000 women in the age range 39 74 years who were randomly assigned receive screening mammograms or not. studies which provided most reliable information showed did not reduce mortality. Studies potentially biased (less carefully done) found reduced However, will result some getting diagnosis even though their would have led death sickness. Currently, it possible tell these are, and they are therefore likely breasts lumps removed radiotherapy unnecessarily. If we assume reduces mortality by 15% after 13 of follow-up overdiagnosis overtreatment at 30%, means for every 2000 invited throughout 10 years, one avoid dying healthy women, been diagnosed if there had screening, treated Furthermore, than 200 experience important psychological distress including anxiety uncertainty because false positive findings. Women should fully informed both benefits harms. To help ensure requirements choice contemplating whether attend programme met, written an evidence-based leaflet lay people available several languages on www.cochrane.dk. Because substantial advances treatment greater awareness since carried out, absolute effect today smaller trials. Recent observational show very little no reduction incidence advanced cancers screening.

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