The Role of Ceramide-1-Phosphate in Biological Functions
作者： L. Alexis Hoeferlin , Dayanjan S. Wijesinghe , Charles E. Chalfant
DOI: 10.1007/978-3-7091-1368-4_8
关键词: Enzyme 、 Cell growth 、 Cell biology 、 Kinase 、 Ceramide kinase 、 Chemistry 、 Synaptic vesicle 、 Knockout mouse 、 Ceramide 、 Sphingolipid
摘要: In mammalian cells, cermide-1-phosphate (C1P) is produced via the ATP-dependent mechanism of converting ceramide to C1P by enzyme, kinase (CERK). CERK was first described as a calcium-stimulated lipid that co-purified with brain synaptic vesicles, and date, only identified enzyme known produce in cells. has steadily emerged bioactive sphingolipid involved cell proliferation, macrophage migration, inflammatory events. The recent generation knockout mouse development inhibitors have furthered our current understanding CERK-derived regulating biological processes. this chapter, history well functions attributed are reviewed.
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