Unit galenical form for local hormonotherapy of vaginal dryness

作者: Catherine Meignant

DOI:

关键词: HomogeneousVaginal drynessBioadhesiveInternal phaseChromatographyAqueous solutionSuspension (chemistry)Materials science

摘要: This galenical form in intended to a local treatment, essentially non systemic, of the vaginal dryness, particularly menopaused women. It comprises free natural oestrogen, micronized or vectorized, selected amongst 17β-estradiol and its salts solution suspension lipophilic agent, with an oestrogen contents corresponding unit dose equivalent 15 νg at most, preferably less than 10 17β estradiol, bioadhesive gelifying hydrophilic agent hydrodispersible agent. on one hand, soft capsule, external solid hard envelope containing gelatine glycerin and, other liquid semi-liquid internal phase suspension, bioadhesion In sustained release ovule form, it semi-soft aqueous homogeneous

参考文章(1)
Majid Mahjour, Bernadette Mauser, Zahra Rashidbaigi, Edwards Eonchao Linn, Compositions with enhanced penetration ,(1989)