A process for the enzymatic reduction of enoates
作者： Melanie Bonnekessel , Clemens Stückler , Bernhard Hauer , Steffen Maurer , Kurt Faber
DOI:
关键词: Carboxyl radical 、 Aldehyde 、 Enzyme 、 NAD+ kinase 、 Protecting group 、 Ketone 、 Stereochemistry 、 Chemistry
摘要: A process for the enzymatic reduction of an enoate (1) wherein C=C bond is stereoselectively hydrogenated in presence enoate-reductase and oxidizable co-substrate (2) a system which free NAD(P)H, a. formula (1); b. c. ketone radical (-CRO), aldehyde (-CHO), carboxyl (-COOR), with R = H or optionally substituted C1-C6-alkyl radical, d. R1, R2 R3 are independently one another H, -O-C1-C6-alkyl, -O-W W hydroxyl protecting group, C1-C6-alkyl, can be substituted, C2-C6-alkenyl, carboxyl, carbo- heterocyclic, aromatic nonaromatic -OH R1 linked to so as become part 4-8-membered cycle, proviso that may not identical.
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