RNAi silencing: A tool for functional genomics research on fungi

作者: Anahí Armas-Tizapantzi , Alba Mónica Montiel-González

DOI: 10.1016/J.FBR.2016.05.003

关键词: RNA silencingGene silencingRegulation of gene expressionComputational biologyBiologyGeneticsFunctional genomicsRNA interferenceModel organismGeneMechanism (biology)

摘要: Abstract RNA interference (RNAi) is a mechanism of post-transcriptional gene silencing which triggered by the presence double stranded molecules homologous to gene, resulting in degradation messenger produced attenuating thereby target expression, as regulation expression. The potential use this several areas life sciences tangible. In case biotechnology, fungi production models human interest compounds, invites studies on mechanisms for better its qualities. This review tries concentrate most existing information about and components that direct silencing, using RNAi fungus model organism. Also, it was included available role organisms contain it. Strategies have been developed tools study function are mentioned, too. Finally, some research where has used assess included.

参考文章(99)
Carmit Ziv, Oded Yarden, Gene silencing for functional analysis: assessing RNAi as a tool for manipulation of gene expression. Methods of Molecular Biology. ,vol. 638, pp. 77- 100 ,(2010) , 10.1007/978-1-60761-611-5_6
Michael J. Berridge, Martin D. Bootman, H. Llewelyn Roderick, Calcium signalling: dynamics, homeostasis and remodelling. Nature Reviews Molecular Cell Biology. ,vol. 4, pp. 517- 529 ,(2003) , 10.1038/NRM1155
Ines A. Drinnenberg, David P. Bartel, Gerald R. Fink, Compatibility with Killer Explains the Rise of RNAi-Deficient Fungi PMC. ,(2011)
Y. Ninomiya, K. Suzuki, C. Ishii, H. Inoue, Highly efficient gene replacements in Neurospora strains deficient for nonhomologous end-joining. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 12248- 12253 ,(2004) , 10.1073/PNAS.0402780101
Andrew Fire, SiQun Xu, Mary K. Montgomery, Steven A. Kostas, Samuel E. Driver, Craig C. Mello, Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature. ,vol. 391, pp. 806- 811 ,(1998) , 10.1038/35888
M. Venkat Rajam, Arthur W. Galston, The Effects of Some Polyamine Biosynthetic Inhibitors on Growth and Morphology of Phytopathogenic Fungi1 Plant and Cell Physiology. ,vol. 26, pp. 683- 692 ,(1985) , 10.1093/OXFORDJOURNALS.PCP.A076958
Nohemi Carreras-Villaseñor, Edgardo U. Esquivel-Naranjo, J. Manuel Villalobos-Escobedo, Cei Abreu-Goodger, Alfredo Herrera-Estrella, The RNAi machinery regulates growth and development in the filamentous fungus Trichoderma atroviride. Molecular Microbiology. ,vol. 89, pp. 96- 112 ,(2013) , 10.1111/MMI.12261
X. Zhang, D. L. Nuss, A host dicer is required for defective viral RNA production and recombinant virus vector RNA instability for a positive sense RNA virus. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 16749- 16754 ,(2008) , 10.1073/PNAS.0807225105