Basophil, Eosinophil, and Neutrophil Functions in the Elderly

摘要: Human granulocytes are classically characterized by their capacity to act as phagocytes, degranulators secreting preformed lytic enzymes from granules, and produce reactive oxygen species (ROS) destroy bacteria, parasites, fungi. Basophils eosinophils mainly involved in the defense against parasites or allergic reactions, but also they play important roles antigen presentation, immune memory response, T helper 2 cell (Th2) differentiation. Like basophils eosinophils, neutrophils function have been underestimated research for a long time. Thus, categorized short-lived phagocytic cells of innate system with limited ability biosynthetic activity being first appearing inflamed locations/acute inflammation fight extracellular pathogens. In last two decades, this view was challenged demonstration that survive much longer than suggested can be induced de novo express genes encoding key inflammatory mediators, including complement components, Fc receptors, chemokines, cytokines. Immune adaptive uniformly compromised aging, contributing high susceptibility infections increased mortality observed elderly. Whereas effects aging on B well documented, studies related age-related defects polymorphonuclear (PMN), basophils, restricted. That is surprising since genetically of, e.g., increase severe mortality. Furthermore, during there shift which raises importance these cells. There consensus about unchanged neutrophil numbers circulation throughout aging; apart this, reports changes tissue infiltration, phagocytosis, burst capabilities aged donors inconsistent. Additionally, many different results between vivo vitro investigating murine human neutrophils. The majority reported discrepancies originate damaged signaling pathways where SENIEUR protocol has not used. Research neutrophils, addition, would build basis drug development preventing and/or fighting diseases. rare despite fact an role allergy, asthma, autoimmune This chapter highlights system, focusing new insights into neutrophil, basophil, eosinophil immunity.