The association between ethnicity and vaginal microbiota composition in Amsterdam, the Netherlands.

摘要: Objective To evaluate whether ethnicity is independently associated with vaginal microbiota (VMB) composition in women living Amsterdam, the Netherlands, as has been shown for American women. Methods Women (18–34 years, non-pregnant, N = 610) representing six largest ethnic groups (Dutch, African Surinamese, South-Asian Turkish, Moroccan, and Ghanaian) were sampled from population-based HELIUS study. Sampling was performed irrespective of health status or healthcare seeking behavior. DNA extracted self-sampled swabs sequenced by Illumina MiSeq (16S rRNA gene V3-V4 region). Results The overall prevalence VMBs not dominated lactobacilli 38.5%: 32.2% had a VMB resembling bacterial vaginosis another 6.2% Bifidobacteriaceae (not including Gardnerella vaginalis), Corynebacterium, pathobionts (streptococci, staphylococci, Proteus Enterobacteriaceae). The most prevalent ethnically Dutch Lactobacillus crispatus-dominated VMB, Surinamese Ghanaian polybacterial G. vaginalis-containing other L. iners-dominated VMB. After adjustment sociodemographic, behavioral clinical factors, (adjusted odds ratio (aOR) 5.1, 95% confidence interval (CI) 2.1–12.0) (aOR 4.8, CI 1.8–12.6) having 2.8, 1.2–6.2). Shorter steady relationship duration, inconsistent condom use casual partners, using hormonal contraception also but human papillomavirus infection not. Other sexually transmitted infections uncommon. Conclusions this cohort aged 18–34 years Amsterdam high (38.5%), sub-Saharan descent significantly more likely to have than independent modifiable behaviors.