Adverse effects of Croton urucurana B. exposure during rat pregnancy.

摘要: Abstract Ethnopharmacological relevance Croton urucurana presents several beneficial pharmacological properties. In Brazil, women who intend to interrupt the pregnancy indiscriminately use extracts of this plant as an abortifacient agent. Aim study To evaluated effect aqueous extract latex on maternal-fetal repercussions in rats. Methods Pregnant rats were randomly distributed into four experimental groups: Control=treated with water (vehicle); Treated 200=treated a dose 200 mg/kg; 400=dose 400 mg/kg and; and 800=dose 800 mg/kg. The orally treated by gavage or vehicle (water) during whole pregnancy. At term pregnancy, all killed obtain maternal blood tissues samples fetal weight anomaly analyses. Results C. treatment (Treated 400 800) showed elevated liver enzymatic activities, reduced body placental efficiency. 800 group presented increased total protein cholesterol levels, heart relative weight. All groups food intake, pre-implantation loss rate compared those Control group. addition, contributed skeletal visceral anomalies higher doses. Conclusion caused toxicity, which for impairment embryo development. These results that indiscriminate plants should be avoided prevent potential risk health well their offspring.