Clinical research in cancer palliative care: a metaresearch analysis

摘要: Objective This metaresearch of the clinicaltrials.gov database aims to evaluate how clinical research on palliative care is conducted within setting advanced cancer. Methods Clinicaltrials.gov was searched identify registered studies recruiting patients with cancer, and investigating issues relevant care. The European Organisation for Research Treatment Cancer QLQ-C15-PAL (Quality Life in cancer patients) questionnaire taken into account define domains interest. Studies cancer-directed therapy, management treatment-related adverse events diagnostic tests were excluded. Publication status crosschecked using PubMed. Results Of 3950 identified studies, 514 included. most frequent reason exclusion therapy (2491). In 2007–2012, 161 versus 245 2013–2018. Included interventional (84%) or observational (16%). Most monocentric (60%), sponsored by academia (79%), North America (57%) Europe (25%). Seventy-nine per cent evaluated a heterogeneous population (>1 tumour type). Interventional frequently investigated systemic drugs (34%), behavioural interventions (29%) procedures pain (24%). Pain, quality life physical function studied (188, 95 52 respectively). applied primary outcome measures efficacy/symptom control (61%), (14%) feasibility (12%). Only 16% closed had published results Conclusions Our study describes landscape address Albeit observed increase number over last decade, generalisation brought existing trials limited due methodological lack reporting. A greater effort needed improve that supports evidence-based