Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

作者: P S Linsley , W Brady , L Grosmaire , A Aruffo , N K Damle

DOI: 10.1084/JEM.173.3.721

关键词: IL-2 receptorAntigen-presenting cellCytotoxic T cellZAP70Interleukin 3T cellMolecular biologyCD28BiologyInterleukin 21

摘要: … B cells by interaction with the B7 antigen. Here we show that CD28 is the primary receptor for B7 on activated peripheral blood T cells, that CD28 binds to B7 in the absence of other …

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