Voluntary activity reverses spermidine-induced myocardial fibrosis and lipid accumulation in the obese male mouse

摘要: Obesity due to high calorie intake induces cardiac hypertrophy and dysfunction, thus contributing cardiovascular morbidity mortality. Recent studies in aging suggest that oral supplementation with the natural polyamine spermidine has a cardioprotective effect. Here, hypothesis was tested or voluntary activity alone combination protect heart from adverse effects induced by obesity. Therefore, C57Bl/6 mice (n = 8–10 per group) were subjected control fat diet (HFD) left untreated, either received via drinking water voluntarily active both. After 30 weeks, killed ventricle of hearts processed for light electron microscopy. Design-based stereology used estimate parameters hypertrophy, fibrosis, lipid accumulation. HFD as demonstrated higher volumes ventricle, cardiomyocytes, interstitium, myofibrils cardiomyocyte mitochondria. These changes not influenced activity. also myocardial fibrosis accumulation droplets within cardiomyocytes. enhanced treated animals but mice. This even case spermidine. In conclusion, data confirm induction ventricular high-fat that—under diet—spermidine enhances interstitial which is counteracted