Tackling reproducibility in academic preclinical drug discovery

作者: Stephen V. Frye , Michelle R. Arkin , Cheryl H. Arrowsmith , P. Jeffrey Conn , Marcie A. Glicksman

DOI: 10.1038/NRD4737

关键词: ReproducibilityMedical physicsMEDLINEDrugDrug discoveryPharmacologySuspectMedicine

摘要: The reproducibility of biomedical research on novel drug targets has become suspect. Here, we highlight how discovery centres embedded in academic institutions, but with a translational imperative, can help address this crisis.

参考文章(5)
Cheryl H Arrowsmith, James E Audia, Christopher Austin, Jonathan Baell, Jonathan Bennett, Julian Blagg, Chas Bountra, Paul E Brennan, Peter J Brown, Mark E Bunnage, Carolyn Buser-Doepner, Robert M Campbell, Adrian J Carter, Philip Cohen, Robert A Copeland, Ben Cravatt, Jayme L Dahlin, Dashyant Dhanak, Aled M Edwards, Mathias Frederiksen, Stephen V Frye, Nathanael Gray, Charles E Grimshaw, David Hepworth, Trevor Howe, Kilian V M Huber, Jian Jin, Stefan Knapp, Joanne D Kotz, Ryan G Kruger, Derek Lowe, Mary M Mader, Brian Marsden, Anke Mueller-Fahrnow, Susanne Müller, Ronan C O'Hagan, John P Overington, Dafydd R Owen, Saul H Rosenberg, Ruth Ross, Bryan Roth, Matthieu Schapira, Stuart L Schreiber, Brian Shoichet, Michael Sundström, Giulio Superti-Furga, Jack Taunton, Leticia Toledo-Sherman, Chris Walpole, Michael A Walters, Timothy M Willson, Paul Workman, Robert N Young, William J Zuercher, The promise and peril of chemical probes. Nature Chemical Biology. ,vol. 11, pp. 536- 541 ,(2015) , 10.1038/NCHEMBIO.1867
Elie Dolgin, Drug discoverers chart path to tackling data irreproducibility Nature Reviews Drug Discovery. ,vol. 13, pp. 875- 876 ,(2014) , 10.1038/NRD4488
Florian Prinz, Thomas Schlange, Khusru Asadullah, Believe it or not: how much can we rely on published data on potential drug targets? Nature Reviews Drug Discovery. ,vol. 10, pp. 712- 712 ,(2011) , 10.1038/NRD3439-C1
Jonathan Baell, Michael A. Walters, Chemistry: Chemical con artists foil drug discovery Nature. ,vol. 513, pp. 481- 483 ,(2014) , 10.1038/513481A
Timothy M Errington, Elizabeth Iorns, William Gunn, Fraser Elisabeth Tan, Joelle Lomax, Brian A Nosek, None, An open investigation of the reproducibility of cancer biology research eLife. ,vol. 3, ,(2014) , 10.7554/ELIFE.04333