The effects of ischaemia, lysophosphatidylcholine and palmitoylcarnitine on rat heart phospholipase A2 activity
作者： J. M. Bentham , A. J. Higgins , B. Woodward
DOI: 10.1007/978-3-662-08390-1_16
关键词: Ischemia 、 Lysophospholipids 、 Phospholipase A2 、 Chemistry 、 Palmitoylcarnitine 、 Carnitine 、 Phospholipase 、 Endocrinology 、 Internal medicine 、 Ligation 、 Lysophosphatidylcholine
摘要: Phospholipase A2 activity was studied in the isolated rat heart following coronary artery ligation. In both homogenate and mitochondrial fractions phospholipase significantly depressed at 20 min post ligation ischaemic region only. This is a time of peak lysophospholipid concentration severity arrhythmias. No such depression seen crude sarcolemmal fraction, possibly due to washout inhibitory factors during isolation. Lysophosphatidylcholine palmitoylcarnitine, two amphiphiles known accumulate ischaemia, were shown be capable inhibiting A2. It suggested that palmitoylcarnitine accumulation ischaemia may contribute decreased metabolism lysophospholipids more importance their than increased production by
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