Histopathological risk factors for ipsilateral breast events after breast conserving treatment for ductal carcinoma in situ of the breast--results from the Swedish randomised trial.

摘要: Aim: The primary aims were to study risk factors for an ipsilateral breast event (IBE) after sector resection ductal carcinoma in situ of the (DCIS) a trial comparing adjuvant radiotherapy no therapy and assess predictive response Secondary analyse reproducibility histopathological evaluation estimate correctness diagnosis trial. Setting: A randomised Sweden (the SweDCIS trial), including 1046 women with median 5.2 years follow-up population, offered routine mammographic screening. Methods: case-cohort design total 161 cases IBE (42 those being members subcohort) 284 sampled sub-cohort. Ninety five percent participants' slides could be retrieved re-evaluated by three experienced pathologists. Results: Low nuclear grade (NG 1-2) absence necrosis halves both irradiated non-irradiated patients. Lesion size, margins excision age at did not modify these associations. presence modified effect radiotherapy: relative was 0.40 present 0.07 absent (p-value interaction 0.068). In all subsets prognostic factors, conferred substantial benefit. invasive similar. agreement between pathologists moderate (kappa = 0.486). Correctness subcohort 84.8%. Conclusion: Although carry information, we define group very low alone. Radiotherapy has protective substrata studied. is clinically biologically relevant research area.