Calculation of isoeffective doses and the α /β value by comparing results following radiosurgery and radiotherapy for arteriovenous malformations of the brain

作者: Bengt Karlsson , Ingmar Lax , Masaaki Yamamoto , Michael Söderman , Hidefumi Jokura

DOI: 10.3171/SUP.2006.105.7.183

关键词: Predictive valueFractionated radiotherapyDose per fractionNuclear medicineTreatment outcomeRadiosurgeryRadiation therapyEffective dose (radiation)MedicineTotal dose

摘要: Object The authors sought to assess the relationship between obliteration rate and different dose parameters following fractionated radiotherapy for arteriovenous malformations (AVMs). A comparison of results radiosurgery AVMs was made calculate best fit α/β value, which would then be used as a model predicting treatment outcome, independent number fractions applied. Methods Data from 1453 patients were analyzed: 1154 treated with 300 radiotherapy. relationships after 3 years calculated, curve empirical defined. higher per fraction, biologically effective dose, lower total rate. isoeffective doses when comparing value could not fraction had predictive fracti...

参考文章(27)
Steiner L, Blomgren H, Arndt J, Lindqvist M, Berggren Bm, Stereotactic radiation therapy of intracranial arteriovenous malformations. Acta Radiologica. ,vol. 369, pp. 610- ,(1986)
Ole Jörgen Kirkeby, Sören Bakke, Kjell Tveraa, Henry Hirschberg, Fractionated Stereotactic Radiation Therapy for Intracranial Arteriovenous Malformations Stereotactic and Functional Neurosurgery. ,vol. 66, pp. 10- 14 ,(1996) , 10.1159/000099660
Hidefumi Aoyama, Hiroki Shirato, Takeshi Nishioka, Kenji Kagei, Rikiya Onimaru, Keishirou Suzuki, Satoshi Ushikoshi, Kiyohiro Houkin, Satoshi Kuroda, Hiroshi Abe, Kazuo Miyasaka, Treatment outcome of single or hypofractionated single-isocentric stereotactic irradiation (STI) using a linear accelerator for intracranial arteriovenous malformation. Radiotherapy and Oncology. ,vol. 59, pp. 323- 328 ,(2001) , 10.1016/S0167-8140(01)00303-6
Bengt Karlsson, Melker Lindqvist, Henric Blomgren, Guo Wan-Yeo, Michael Söderman, Ingmar Lax, Masaaki Yamamoto, Julian Bailes, Long-term results after fractionated radiation therapy for large brain arteriovenous malformations. Neurosurgery. ,vol. 57, pp. 42- 49 ,(2005) , 10.1227/01.NEU.0000163095.56638.26
Eric J. Hall, David J. Brenner, The radiobiology of radiosurgery: Rationale for different treatment regimes for AVMs and malignancies International Journal of Radiation Oncology Biology Physics. ,vol. 25, pp. 381- 385 ,(1993) , 10.1016/0360-3016(93)90367-5
Bengt Karlsson, Lars Kihlström, Christer Lindquist, Ladislau Steiner, Gamma knife surgery for previously irradiated arteriovenous malformations. Neurosurgery. ,vol. 42, pp. 1- 5 ,(1998) , 10.1097/00006123-199801000-00001
Bengt Karlsson, Ingmar Lax, Michael S̈oderman, Can the probability for obliteration after radiosurgery for arteriovenous malformations be accurately predicted International Journal of Radiation Oncology Biology Physics. ,vol. 43, pp. 313- 319 ,(1999) , 10.1016/S0360-3016(98)00396-4
Francesco Tognetti, Alvaro Andreoli, Anna Cuscini, Claudio Testa, Successful management of an intracranial arteriovenous malformation by conventional irradiation. Journal of Neurosurgery. ,vol. 63, pp. 193- 195 ,(1985) , 10.3171/JNS.1985.63.2.0193
John C Flickinger, Douglas Kondziolka, Ann H Maitz, L Dade Lunsford, An analysis of the dose-response for arteriovenous malformation radiosurgery and other factors affecting obliteration. Radiotherapy and Oncology. ,vol. 63, pp. 347- 354 ,(2002) , 10.1016/S0167-8140(02)00103-2
Peter Lindvall, Per Bergström, Per-Olov Löfroth, Marwan I. Hariz, Roger Henriksson, Per Jonasson, A. Tommy Bergenheim, Hypofractionated conformal stereotactic radiotherapy for arteriovenous malformations. Neurosurgery. ,vol. 53, pp. 1036- 1043 ,(2003) , 10.1227/01.NEU.0000088566.82699.E6