Synthesis of anti-allergic drugs

摘要: Histamine is formed by the decarboxylation of histidine catalyzed enzymes. It an endogenous biologically active substance involved in multiple complex physiological processes as important chemical transmitter. receptors have four subtypes, H1, H2, H3 and H4, all which are G protein coupling (GPCRs) with different functions. plays role pathophysiological mechanism allergic diseases, antagonistic effect histamine has become way to study anti-allergic drugs, wherein drugs used clinical practice mainly H1 receptor antagonists. Currently, there many varieties antagonists applications, can be divided into ethylenediamine antagonists, amino ether propylamine tricyclic piperazine piperidine depending on their structures. This article reviews research progress reactions expounds aspects design synthesis various new compounds.