Catalytic mechanism and regulation of mammalian adenylyl cyclases.
作者： Wei-Jen Tang , James H. Hurley
DOI: 10.1124/MOL.54.2.231
关键词: Mechanism (biology) 、 Ion channel 、 Hormone 、 Cell biology 、 Biology 、 Adenylyl Cyclases 、 Chemokine 、 Cell 、 Second messenger system 、 Biochemistry 、 Membrane potential
摘要: cAMP is a key player in the intracellular signaling pathways of hormones, neurotransmitters, odorants, and chemokines. By activating PKA cyclic nucleotide-gated ion channels, this protean second messenger can change cellular attributes as diverse membrane potential rate cell
sci-hub.se 参考文章(77)
Sylvie Doublié, Stanley Tabor, Alexander M. Long, Charles C. Richardson, Tom Ellenberger, Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution Nature. ,vol. 391, pp. 251- 258 ,(1998) , 10.1038/34593
D. M. F. Cooper, N. Mons, J. C. Zwaagstra, J. Krupinski, J. J. Cali, Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain. Journal of Biological Chemistry. ,vol. 269, pp. 12190- 12195 ,(1994) , 10.1016/S0021-9258(17)32700-X
Gregor Zimmermann, Ronald Taussig, Protein Kinase C Alters the Responsiveness of Adenylyl Cyclases to G Protein α and βγ Subunits Journal of Biological Chemistry. ,vol. 271, pp. 27161- 27166 ,(1996) , 10.1074/JBC.271.43.27161
S G Somkuti, J D Hildebrandt, J T Herberg, R Iyengar, Divalent cation regulation of adenylyl cyclase. An allosteric site on the catalytic component. Journal of Biological Chemistry. ,vol. 257, pp. 6387- 6393 ,(1982) , 10.1016/S0021-9258(20)65153-5
E J Neer, J M Lok, L G Wolf, Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase. Journal of Biological Chemistry. ,vol. 259, pp. 14222- 14229 ,(1984) , 10.1016/S0021-9258(18)89881-7
Nikolai P. Skiba, Heidi E. Hamm, How Gsα activates adenylyl cyclase Nature Structural & Molecular Biology. ,vol. 5, pp. 88- 92 ,(1998) , 10.1038/NSB0298-88
J. Kawabe, G. Iwami, T. Ebina, S. Ohno, T. Katada, Y. Ueda, C.J. Homcy, Y. Ishikawa, Differential activation of adenylyl cyclase by protein kinase C isoenzymes. Journal of Biological Chemistry. ,vol. 269, pp. 16554- 16558 ,(1994) , 10.1016/S0021-9258(19)89424-3
F Eckstein, P J Romaniuk, W Heideman, D R Storm, Stereochemistry of the mammalian adenylate cyclase reaction. Journal of Biological Chemistry. ,vol. 256, pp. 9118- 9120 ,(1981) , 10.1016/S0021-9258(19)52516-9
Z Wu, S.T. Wong, D.R. Storms, Modification of the calcium and calmodulin sensitivity of the type I adenylyl cyclase by mutagenesis of its calmodulin binding domain Journal of Biological Chemistry. ,vol. 268, pp. 23766- 23768 ,(1993) , 10.1016/S0021-9258(20)80447-5
W.J. Tang, J. Krupinski, A.G. Gilman, Expression and characterization of calmodulin-activated (type I) adenylylcyclase Journal of Biological Chemistry. ,vol. 266, pp. 8595- 8603 ,(1991) , 10.1016/S0021-9258(18)93016-4