The apolipoprotein E epsilon 4 allele is associated with increased neuritic plaques and cerebral amyloid angiopathy in Alzheimer's disease and Lewy body variant
作者： J. M. Olichney , L. A. Hansen , D. Galasko , T. Saitoh , C. R. Hofstetter
DOI: 10.1212/WNL.47.1.190
关键词: Senile plaques 、 Psychology 、 Alzheimer's disease 、 Cerebral amyloid angiopathy 、 Apolipoprotein E 、 Pathology 、 Degenerative disease 、 Central nervous system disease 、 Amyloid 、 Lewy body
摘要: Objective: To determine the relationship between apolipoprotein E (apoE) genotype and neuropathologic lesions in Alzheimer9s disease (AD) Lewy body variant (LBV). Design: Retrospective genetic-neuropathologic study of AD LBV cases. The main outcome measures were modeled as a function apoE genotype, diagnosis, gender. Age at death duration symptom effects controlled for by ANCOVA. Patients: One hundred twenty-seven cases with neuropathologically diagnosed (n = 84) or 43). Main measures: Quantitative scores neuritic plaques (NPs), neurofibrillary tangles (NFTs), cerebral amyloid angiopathy (CAA) severity, CAA prevalence averaged across four brain regions: midfrontal, inferior parietal, superior temporal, hippocampal. Results: epsilon 4 allele was associated increased NPs within both LBV. an frequency groups combined alone. While severity NFTs 4/4 homozygous when combined, there no significant Conclusions: is strongly NPs, but not neocortical NFTs, NEUROLOGY 1996;47: 190-196
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sci-hub.se 参考文章(20)
T. C. Smyrk, Colon cancer connections. Cancer syndrome meets molecular biology meets histopathology. American Journal of Pathology. ,vol. 145, pp. 1- 6 ,(1994)
A.B. Jaffe, C.D. Toran-Allerand, P. Greengard, S.E. Gandy, Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein. Journal of Biological Chemistry. ,vol. 269, pp. 13065- 13068 ,(1994) , 10.1016/S0021-9258(17)36796-0
Roger N. Rosenberg, Autosomal dominant cerebellar phenotypes: The genotype has settled the issue Neurology. ,vol. 45, pp. 1- 5 ,(1990) , 10.1212/WNL.45.1.1
C. A. Ryan, Oligosaccharide signals: from plant defense to parasite offense Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 1- 2 ,(1994) , 10.1073/PNAS.91.1.1
M. Gasset, M. A. Baldwin, R. J. Fletterick, S. B. Prusiner, Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 1- 5 ,(1993) , 10.1073/PNAS.90.1.1
Rebecca Voelker, Foodborne Illness Problems More Than Enteric JAMA: The Journal of the American Medical Association. ,vol. 271, pp. 8- 11 ,(1994) , 10.1001/JAMA.1994.03510250016005
Charles M. Poser, Armand Lowenthal, Ludo van Bogaert (1897–1989) Journal of the Neurological Sciences. ,vol. 95, pp. 1- 2 ,(1990) , 10.1016/0022-510X(90)90112-Z
L. Hansen, D. Salmon, D. Galasko, E. Masliah, R. Katzman, R. DeTeresa, L. Thal, M. M. Pay, R. Hofstetter, M. Klauber, V. Rice, N. Butters, M. Alford, The Lewy body variant of Alzheimer's disease A clinical and pathologic entity Neurology. ,vol. 40, pp. 1- 1 ,(1990) , 10.1212/WNL.40.1.1
M. J. Kupersmith, D. Kaufman, D. W. Paty, G. Ebers, H. McFarland, K. Johnson, S. Reingold, J. Whitaker, Megadose corticosteroids in multiple sclerosis. Neurology. ,vol. 44, pp. 1- 4 ,(1994) , 10.1212/WNL.44.1.1
P.L. Deangelis, N. Yang, P.H. Weigel, The Streptococcus pyogenes hyaluronan synthase : sequence comparison and conservation among various group A strains Biochemical and Biophysical Research Communications. ,vol. 199, pp. 1- 10 ,(1994) , 10.1006/BBRC.1994.1184