Radiation treatment in early stage triple-negative breast cancer in New Zealand: A national database study.

摘要: INTRODUCTION We aimed to investigate the impact of radiation treatment in early-stage triple negative breast cancer (TNBC). METHODS Patients with early stage (T1-3, N0-2, M0) TNBC were identified using New Zealand register. The outcomes local recurrence (LRFR), free survival (LRFS), loco-regional rate (LRRFR), (LRRFS), specific (BCSS), metastasis (MFS) and overall (OS) determined. Predefined univariate multivariate cox regression analyses used explore associations between known prognostic factors. RESULTS 1209 patients a median follow-up 3.88 years. majority post- menopausal. mean tumour size was 26mm, had grade III disease third node positive. 625 mastectomy 584 conservation surgery (BCS). 92% BCS 38% received radiation. 67% adjuvant chemotherapy. 5 year OS 77.6% (95% CI 74.6-80.2), BSS 82.1% (95%CI 79.1-84.7), LRRFS 73.9% 73.87-73.93), LRFS 75.4 (75.37-75.43) LRFR 92.4% 90.6-94.2). significant prognostic/predictive factors for treatment, chemotherapy, T stage, lymph involvement lympho-vascular space invasion. Results similar BSS, DMFS, except that LVSI not significantly associated BCSS, or LRRFS. When analysed by surgical type, WLE group, found be improvement all outcomes. In LRFS, OS. CONCLUSION Radiation is improved TNBC. This argues against hypothesis has inherent resistance.