Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas' disease.

摘要: The major goal of studies on immunity to Trypanosoma cruzi is the understanding immunological mechanisms involved in resistance this protozoan as well pathogenesis Chagas' disease. Different have defined CD8+ T lymphocytes, IFN-gamma and macrophages important elements controlling parasite replication during acute phase infection. In contrast, chronic stage disease parasite-specific antibodies that fix complement lyse blood from trypomastigotes are thought be main effector molecules responsible for maintaining latent both infection with T. CD4+ Th1 lymphocytes appear cells induction protective immunity. much more controversial. cardiac tissue destruction. Although many experiments suggest involvement autoimmunity disease, recent mice humans indicate a positive association parasitism, inflammation severity pathology induced by cruzi. Finally, has emerged an opportunistic pathogen patients infected HIV presenting low numbers lymphocytes. These clinical findings essential requirement T-helper mediating disease; however, control reactivation vivo not completely defined.