作者: Y.-S. Zhu , J. Imperato-McGinley
DOI: 10.1016/B978-008088783-8.00088-7
关键词: Androgen receptor 、 Testosterone 、 Physiology 、 Internal medicine 、 Testis determining factor 、 Sexual dimorphism 、 Hormone 、 Endocrinology 、 Androgen 、 Biology 、 Sexual differentiation 、 Androgen insensitivity syndrome
摘要: Male sexual differentiation is a complex process of events involving genetic and hormonal factors, with androgens playing major role. The formation testes in 46,XY individuals establishes the male gonadal sex. Hormones produced by testes, especially testosterone anti-Mullerian hormone, play essential roles differentiation; conversely, defects production action these hormones result disorders differentiation. In this chapter, factors controlling are reviewed. By discussing subjects androgen action, particularly those 17β-hydroxysteroid dehydrogenase-3 deficiency, 5α-reductase-2 insensitivity syndrome, differentiation, gender identity, cognitive function emphasized. issue interaction nature versus nurture addressed.