Sensitivity enhancement for capillary zone electrophoresis-mass spectrometry: Developments and applications.
DOI:
关键词: Direct electron ionization liquid chromatography–mass spectrometry interface 、 Selected reaction monitoring 、 Electrospray ionization 、 Mass spectrometry 、 Sample preparation in mass spectrometry 、 Chromatography 、 Extractive electrospray ionization 、 Chemistry 、 Liquid chromatography–mass spectrometry 、 Analytical chemistry 、 Capillary electrophoresis–mass spectrometry
摘要: Advances in mass spectrometry (MS), i.e., electrospray ionization and tandem using triple quadrupole instruments, have greatly enhanced the analysis of biopolymers, such as proteins glycoproteins. Electrospray enables direct coupling liquid-based separations with spectrometric detection. Capillary zone electrophoresis (CZE) allows for high resolution separation biomolecules, its inherent low flow rate is ideally suited to (ESMS). A major shortcoming CZE concentration detection limits relative liquid chromatography. This thesis presents two approaches improvement sensitivity CZE. These improved methods are applied characterization glycoproteins by CZE-ESMS.
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