‘To bead or not to bead?’ Treatment of osteomyelitis and prosthetic joint-associated infections with gentamicin bead chains

摘要: Gentamicin-containing polymethylmethacrylate (PMMA) beads are frequently used to prevent and treat orthopaedic infections. The typically inserted fill anatomical defects secondary surgical debridement. Local gentamicin use results in low serum levels whilst achieving high concentrations at the site of infection. However, a systematic review available literature showed that, despite these theoretical advantages, no prospective study has thus far proven gentamicin-containing PMMA be effective treating Available studies based on small patient numbers do not show significantly better when local parenteral antibiotics combined compared with systemic therapy alone. These poor may explained partially by reduced aminoglycoside efficacy biofilms or gentamicin-resistant bacteria present. Moreover, little is known regarding potential side effects beads. In this paper, pros cons discussed. It concluded that more well-executed, needed settle discussion treatment