The effect of air pollution on human physiological function in China: a longitudinal study

摘要: Abstract Background Air pollution has been identified as a terrible environmental problem in China. However, no study systematically assessed whether air adverse effects on human physiological function. Methods This was based longitudinal data collected by the Kailuan Cohort Study, which conducted area of community, Tangshan City, 11 hospitals were responsible for health care community. We only used cohort between 2006 and 2008, we had these two years' data. each participant twice with standardised questionnaire assessment, examination, laboratory assessment. The examination assessment included heart function, renal haematopoietic metabolic endocrine liver inflammatory response individual characteristics (age, sex, weight, height, smoking status, drinking physical activity, dietary salt intake, financial income, work type, education level, medical history, etc). Community level daily concentrations particles (PM 10 ), sulphur dioxide (SO 2 ) nitrogen (NO provided Environmental Monitoring Centre. generalised additive mixed models to examine community pollutants while controlling random participants other potential confounders. approved University Queensland's behaviour social sciences ethical review committee (2014001075). Written informed consent obtained participant. Findings Out 155 418 residents, 101 510 (65·31%; 81 110 (82%) men 20 400 women) who written consent, enrolled since 2006. followed up 27 685 2008. Age ranged from 18 90 years, mean 47 years (SD 11·3). About 60% not smokers or drinkers prevalence diabetes 7·7% 2006, 20·9% history hypertension. Increased PM , SO NO significantly associated decreases all categories such increase rate blood pressure (heart function), urine creatinine urea (renal decrease haemoglobin white cell (hematopoietic cholesterol, low-density lipoprotein, high-density ratio lipoprotein (metabolic serum albumin, glutamic-pyruvic transaminase, total bilirubin (liver C-reactive protein (inflammatory function). Generally, elderly people, women, people overweight more susceptible than young men, normal weight. Interpretation could systemically damage Effective control is essential disease prevention. estimate exposures rather personal exposure may underestimate Funding Queensland Research Fellowship (YG). No funding bodies any role design, collection analysis, decision publish, preparation manuscript.