Naturally-occurring shikonin analogues--a class of necroptotic inducers that circumvent cancer drug resistance.
作者： Yanyan Xuan , Xun Hu
DOI: 10.1016/J.CANLET.2008.09.029
关键词: Inducer 、 Cancer 、 Necroptosis 、 Drug resistance 、 ATP-binding cassette transporter 、 Chemistry 、 Cell culture 、 Cancer drugs 、 Apoptosis 、 Pharmacology
摘要: We previously reported that shikonin could circumvent drug resistance mediated by P-gp, Bcl-2 and Bcl-xL, induction of necroptosis. Here, we show the naturally-occurring analogues (deoxyshikonin, acetylshikonin, isobutyrylshikonin, beta,beta-dimethylacrylshikonin, isovalerylshikonin, alpha-methyl-n-butylshikonin) bypass not only Bcl-2, but also two additional important drug-resistant factors MRP1 BCRP1, The results strengthen previous findings necroptotic a broad spectrum cancer resistance.
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