The genetic architecture of odor-guided behavior in Drosophila melanogaster.
作者： Robert R. H. Anholt , Trudy F. C. Mackay
关键词: Drosophila melanogaster 、 Genetics 、 Phenotype 、 Transposon tagging 、 Functional genomics 、 Olfaction 、 Epistasis 、 Genetic architecture 、 Gene 、 Biology
摘要: The avoidance response to repellent odorants in Drosophila melanogaster, a essential for survival, provides an advantageous model studies on the genetic architecture of behavior. Transposon tagging highly inbred strain flies combination with rapid and simple statistical behavioral assay enables identification not only large phenotypic effects, but also small aberrations from wild-type recent completion sequence genome facilitates molecular characterization transposon-tagged genes correlation between gene expression behavior smell-impaired (smi) mutant lines. Quantitative analyses collection smi lines coisogenic background revealed extensive network epistatic interactions among that shape olfactory response. functional proteins encoded by form part subgenome polymorphisms these variation odor-guided natural populations will advance our understanding chemosensory
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