Vaginal Lactobacillus gasseri CMUL57 can inhibit herpes simplex type 2 but not Coxsackievirus B4E2

作者: Imad Al Kassaa , Didier Hober , Monzer Hamze , Delphine Caloone , Anny Dewilde

DOI: 10.1007/S00203-015-1101-8

关键词: CoxsackievirusViral envelopeCytopathic effectLactobacillus gasseriVirologyBiologyVirusViral Plaque AssayMicrobiologyLactobacillusVero cellGeneticsBiochemistryMolecular biologyGeneral Medicine

摘要: This study aimed at demonstrating the antiviral activity of Lactobacillus gasseri CMUL57 (L. CMUL57), L. acidophilus CMUL67 and plantarum CMUL140 against herpes simplex type 2 (HSV-2) Coxsackievirus B4E2 (CVB4E2), which are enveloped naked viruses, respectively. These lactobacilli were non-cytotoxic able to reduce cytopathic effect induced by HSV-2 in Vero cell monolayers. However, not active CVB4E2. Tested displayed anti-HSV-2 when they co-incubated with virus prior inoculating mixture The detection DNA PCR pellets bacteria/virus mixtures let us hypothesize that resulted from viruses' entrapment. showed capabilities vaginal inhibit viruses such as HSV-2.

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