Interleukin 2 induces gamma-interferon production: participation of macrophages and NK-like cells.

摘要: Interleukin 2 (IL 2) has been shown to be a potent stimulator of natural killer (NK) cells. In the present studies, partially purified mouse and human IL preparations were also found induce interferon (IFN) from spleen By criteria sensitivity treatment at pH failure neutralized by anti-alpha, beta IFN serum, species produced was type gamma. Cooperation between two types cell, macrophage an NK-like required for production murine cells treated with 2. The requirement macrophages could replaced supernatant obtained incubating 24 hr lymphokine containing Interestingly, mature T apparently played no role in process. Furthermore, beige (bg/bg) mutation, which severely impairs NK cell lytic activity, had effect on ability participate production. Cell fractionation experiments revealed dissociation requirements augmentation cytotoxic activity production, it is concluded that least portion boosting induced 2-containing mediated through gamma-IFN.