Particle Size and Shape Control in Crystallization Processes
作者： Shinji Hasebe , Richard D. Braatz
DOI:
关键词: Unit operation 、 Crystallization 、 Control engineering 、 Filtration 、 Downstream (manufacturing) 、 Particle size 、 Estimation theory 、 Process engineering 、 Stability (probability) 、 Materials science 、 Shape control
摘要: Crystallization from solution is an industrially important unit operation due to its ability provide high purity separations. The control of the crystal size distribution can be critically for efficient downstream operations such as filtration and drying, product effectiveness (e.g., bioavailability, tablet stability). This paper provides overview on recent developments in industrial crystallization processes. includes descriptions activities modeling, parameter estimation, state analysis, simulation, optimization, control, design
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