Urokinase-type Plasminogen Activator (uPA) Binding to the uPA Receptor (uPAR) Promotes Axonal Regeneration in the Central Nervous System.

摘要: Axonal injury is a common cause of neurological dysfunction. Unfortunately, in contrast to axons from the peripheral nervous system, limited capacity regeneration central system (CNS) major obstacle for functional recovery patients suffering diseases that involve subcortical white matter. Urokinase-type plasminogen activator (uPA) serine proteinase upon binding urokinase-type receptor (uPAR) catalyzes conversion into plasmin on cell surface. uPAR expression increases after an injury, and signaling through promotes tissue remodeling. However, it yet unknown whether uPA has effect axonal CNS. Here, we used vitro vivo models CNS test hypothesis We found newly formed growth cones re-emerging express this by mechanism does not require generation plasmin. Our data indicate recombinant or endogenous induces membrane recruitment activation β1 integrin via low density lipoprotein receptor-related protein-1 (LRP1), which leads Rho family small GTPase Rac1 Rac1-induced regeneration. results show uPA/uPAR/LRP1 potential target development therapeutic strategies promote following injury.