Effects of prolonged administration of the 19-nor-testosterone derivatives norethindrone and norgestrel to female NZB/W mice: comparison with medroxyprogesterone and ethinyl estradiol.

摘要: To evaluate effects of commonly used progestational estrogenic contraceptive steroids in a hormone-responsive model lupus, we treated female NZB/W mice before clinical disease (6 wks age) and after onset lupus (24 with doses hormones titered to suppress reproduction. We report efficacy norethindrone (NE) norgestrel (NG), progestins derived from 19-nor-testosterone, delaying expression anti-DNA antibodies. Mice implanted NG at 24 age had prolonged lifespans. In contrast, the hydroxyprogesterone derivative, medroxyprogesterone acetate (MP), did not affect autoimmune disease. These observations suggest that administration 19-nor-testosterone derivatives, small adequate reproduction, may have ameliorative systemic erythematosus. receiving ethinyl estradiol (EE) plus courses tetracycline cystitis active responses. 60% EE-treated mice, however, early deaths resulted mal...