Androgen function in the pathophysiology and treatment of male Huntington's disease patients.
作者： M. I. Ransome
DOI: 10.1111/J.1365-2826.2012.02347.X
关键词: Huntington's disease 、 Pathophysiology 、 Psychosis 、 Dementia 、 Internal medicine 、 Endocrinology 、 Androgen 、 Psychology 、 Testosterone (patch) 、 Androgen receptor 、 Disease
摘要: Low concentrations of circulating testosterone have been associated with dementia manifesting advancing age and in neurodegenerative conditions. Huntington's disease (HD) is a dominantly inherited an invariably fatal outcome. Severe motor symptoms, psychosis are symptomatic hallmarks the progression HD that result from dysfunction death neocortical basal ganglia neurones. Treatments directed toward manifest although they largely ineffectual slowing or preventing progression. Emerging data identified hypothamic pathologies endocrine disturbances. Clinically defined primary secondary hypogonadism elicit low linked to development Alzheimer's men. Examining similar neuroendocrine including nature male patients could allow elucidation complex pathophysiology provide impetus for hitherto untested replacement therapy.
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