Proliferative changes in the prostate
作者： Parviz Pour , Terence A. Lawson , Samuel M. Cohen
DOI: 10.1016/0041-008X(89)90198-1
关键词: Estrogen 、 Endocrinology 、 Cell growth 、 Biology 、 Carcinogenesis 、 Prostate 、 Rat Prostate 、 Internal medicine 、 Carcinogen 、 Toxicology 、 Pharmacology
摘要: The prostate of the rat has several lobes which have variable responsiveness to estrogens and testosterone. Testosterone is a major stimulant cell proliferation in prostate. Chemical carcinogenesis models taken advantage administering carcinogen during peak proliferative period following testosterone administration with subsequent administered continue stimulus. Invasive adenocarcinomas been induced utilizing such methods.
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