Mitochondrial DNA mutations in respiratory complex‐I in never‐smoker lung cancer patients contribute to lung cancer progression and associated with EGFR gene mutation

摘要: Mitochondrial DNA (mtDNA) mutations were reported in different cancers. However, the nature and role of mtDNA mutation never-smoker lung cancer patients including with EGFR KRAS gene are unknown. In present study, we sequenced entire mitochondrial genome (16.5 kb) matched normal tumors obtained from 30 current-smoker patients, determined content. All patients’ samples for (exon 2) 19 21) mutation. The impact forced overexpression a respiratory complex-I was evaluated cell line. We observed significantly higher (P=0.006) never-smokers compared to patients. MtDNA (P=0.026) Asian Caucasian population. (P=0.007) associated also significant increase (P=0.037) content among majority coding targeted one these resulted increased vitro proliferation, invasion superoxide production cells. prevalence new relationship between alterations Moreover, representative produced strong growth effects after Signature provide basis develop novel biomarkers therapeutic strategies