Enhanced reclosure of surgically induced spinal open neural tube defects in chick embryos by injecting human bone marrow stem cells into the amniotic cavity.

作者: Do-Hun Lee , Ji Hoon Phi , Seung-Ki Kim , Byung-Kyu Cho , Seung U. Kim

DOI: 10.1227/01.NEU.0000371048.76494.0F

关键词: DiseaseKidney diseaseEncephalopathyInternal medicineWhite matterMedicineDiabetes mellitusStenosisSurgerySingle CenterInternal carotid artery

摘要: INTRODUCTION The coronavirus disease 2019 (COVID-19) pandemic that is caused by severe acute respiratory syndrome 2 (SARS-CoV-2) infection has had a dramatic impact on healthcare systems and variable course Emerging evidence demonstrates SARS-CoV-2 associated with central nervous system (CNS) In this series, we describe CNS manifestations in critical COVID-19 patients at our tertiary academic center METHODS A single retrospective cross-sectional analysis of all admitted to care New Orleans, Louisiana April 22, 2020, who were condition due developed new onset neurological Patients grouped into one three categories according imaging clinical features: encephalopathy, necrotizing vasculopathy RESULTS total 27 76 (35 5%) met inclusion criteria Mean age was 59 8 years (range 35–91 years) most an underlying medical condition, including hypertension (63%), diabetes mellitus type (52%), obesity (26%), and/or chronic kidney (22%) Sixty percent injury CT, 30% MRI, 15% non-invasive vascular imaging, 44% EEG CT findings often included subacute ischemic strokes, diffuse hypoattenuation, subcortical parenchymal hemorrhages, focal hypodensities within deep structures MRI involvement white matter, the corpus callosum, basal ganglia For stroke, consisted irregular proximal stenosis supraclinoid internal carotid artery Twenty (74%) designated two (7%) five (19%) CONCLUSION one-day snapshot admissions LA revealed high percentage Although presentations varied, they broadly categorized better understanding sequalae radiographic will help clinicians mitigate

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