Novel Alternating Current Electrospinning of Hydroxypropylmethylcellulose Acetate Succinate (HPMCAS) Nanofibers for Dissolution Enhancement: The Importance of Solution Conductivity

摘要: Novel, high-yield alternating current electrospinning (ACES) and direct methods were investigated to prepare high-quality hydroxypropylmethylcellulose acetate succinate (HPMCAS) fibers for the dissolution enhancement of poorly soluble spironolactone. Although HPMCAS is great pharmaceutical importance as a carrier marketed solid dispersion-based products, it was found be unprocessable using electrospinning. Addition small amounts polyethylene oxide aid polymer provided smooth with but strongly beaded products ACES. Solution characteristics thus modified by introducing further excipients. In presence sodium dodecyl sulfate, high-quality, HPMCAS-based obtained even at higher throughput rates ACES owing change in conductivity (rather than surface tension). Replacement sulfate non-surface-active salts (calcium chloride ammonium acetate) maintained fine quality nanofibers, confirming process. The contained spironolactone an amorphous form according differential scanning calorimetry X-ray powder diffraction. vitro tests revealed fast drug release depending on salt used adjust conductivity. presented results signify that can prospective process high-scale production fibrous dispersions which solution has fundamental role.