Endocannabinoid Modulation in the Olfactory Epithelium
作者： Esther Breunig , Dirk Czesnik , Fabiana Piscitelli , Vincenzo Di Marzo , Ivan Manzini
DOI: 10.1007/978-3-642-14426-4_11
关键词: Endocannabinoid system 、 Central nervous system 、 Olfactory receptor 、 Biology 、 Neuroscience 、 Olfactory system 、 Olfactory epithelium 、 Cannabinoid receptor 、 Sensory system 、 Olfactory receptor neuron
摘要: Appetite, food intake, and energy balance are closely linked to the endocannabinoid system in central nervous system. Now, modulation has been discovered peripheral olfactory of larval Xenopus laevis. The 2-AG shown influence odorant-detection thresholds according hunger state animal. Hungry animals have increased levels due enhanced synthesis sustentacular supporting cells. This renders receptor neurons, exhibiting CB1 receptors, more sensitive at detecting lower odorant concentrations, which probably helps animal locate food. Since taste vision also influenced by endocannabinoids, this kind might boost sensory inputs hungry animals.
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