Collective properties of insulin-secreting cells
作者： ARTHUR SHERMAN , JOHN RINZEL
DOI: 10.1016/B978-0-12-287960-9.50011-3
关键词: Depolarization 、 Biophysics 、 Potassium channel 、 Negative feedback 、 Biochemistry 、 Bursting 、 Bistability 、 Calcium 、 Steady state (electronics) 、 Phase (waves) 、 Chemistry
摘要: Publisher Summary This chapter discusses the collective properties of insulin-secreting cells. Calcium functions as part a dual negative feedback system, involving both electrical activity and secretion. removal leads to depolarization terminates silent phase by deactivating calcium-activated potassium channels. activates voltage-gated calcium HH-like channels, initiates spiking. The ensuing influx ultimately inhibits spiking accumulates. connection with secretion is through glucose metabolism, which increases levels in blood, provides energy for removal. Bistability fast subsystem underlies models' bursting behavior. lower steady state slowly tracked during phase, limit cycle oscillations around depolarized level correspond spikes active phase. view shows how begins when coalesces saddle point. When minimum voltage spike meets rising threshold, terminates.
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